科研课题与成果.pdf
科研课题与成果.pdf
科研课题、获奖、论文、专著及专利 近五年，中心教师主持国家自然科学基金 42 项，其中国际合作课题 2 项，主持 省部级科研基金 48 项、校企横向合作课题 15 项，总计获得科研经费 3300.57 万元； 发表论文 266 篇，其中 SCI 论文 217 篇；获得专利 19 项。 承担课题情况一览表 国家级课题 序 号 课题 项目 负责人 项目 时间 1 与幼年型粒单细胞性白血病相关的 SHP2 突 变体 E76K、D61G 选择性抑制剂的设计、合 成及其活性研究 王润玲 国家自然科学基金 2018.1-2021.12 2 掺杂剂介导的液晶印迹手性传递色谱固定 相的构建及其研究 黄艳萍 国家自然科学基金 2018.1-2021.12 3 基于 p7 三维核磁结构抗丙肝病毒抑制剂研 究 王树青 国家自然科学基金 2018.1-2021.12 4 抗肿瘤转移先导化合物 ION-31a 的衍生合 成、分子机制及靶点研究 段宏泉 国家自然科学基金 2017.1-2020.12 5 STELB 抑制胶质母细胞瘤的作用、分子机制 及靶点研究 孔德新 国家自然科学基金 2017.1-2020.12 6 通过 IgE 受体 FcεRI 激活的肥大细胞抑制 乳腺癌生长的作用及机理研究 金美花 国家自然科学基金 2017.1-2020.12 7 靶向抑制 PI3K 联合 Imatinib 在 BCR-ABL 介导的慢性粒细胞白血病中药物协同机制 研究 邱玉玲 国家自然科学基金 2017.1-2019.12 8 基于可逆反应与谱线比例方式检测谷胱甘 肽新型 EPR 探针的设计、合成及性能研究 韩贵芳 国家自然科学基金 2017.1-2019.12 9 小肠靶向释放 NO 前药作为 P-gp 抑制剂促 进 P-gp 底物药物口服吸收的研究 侯静丽 国家自然科学基金 2017.1-2019.12 10 基于胶体晶体为牺牲模板制备三维有序大 孔结构分子印迹色谱固定相的研究 王涎桦 国家自然科学基金 2017.1-2019.12 11 融合智能递药及干细胞组织工程技术的肢 体缺血再生治疗 贺慧宁 国家自然科学基金 2016.12-2019.1 2 12 以 SHP2 为靶点的抗白血病药物的设计、 合成及活性筛选 王润玲 国家自然科学基金 2016.1-2018.12 王银松 国家自然科学基金 2016.1-2019.12 13 联合声动力、化疗与免疫疗法的多功能纳 米治疗体系的构建及其靶向抗肝癌作用研 究 14 新型双自由基氧化还原探针的开发及性能 研究 刘阳平 国家自然科学基金 2016.1-2019.12 15 基于 trityl 自由基的超氧自旋捕捉剂的分 子设计、合成及性能研究 宋玉光 国家自然科学基金 2016.1-2018.12 16 肿瘤细胞外膜蛋白 MMP-14 提高透膜性细胞 穿透肽共轭物膜外周选择性富集的研究 孙璐 国家自然科学基金 2015.1-2017.12 17 基于肿瘤靶向及特异性激活的“前药”性 大分子药物给药系统治疗结肠癌的研究 贺慧宁 国家自然科学基金 2015.1-2017.12 18 针对多药耐药肿瘤的可视化 pH 敏感主动靶 向给药系统的研究 高薇 国家自然科学基金 2015.1-2017.12 19 基于"Build-and-Click"法的铂类 RNA 聚合 酶 I 选择性抑制剂的构建、评价 乔鑫 国家自然科学基金 2015.1-2017.12 20 新型微柱细胞膜色谱及其在抗体类药物质 量控制中的应用 徐亮 国家自然科学基金 2015.1-2017.12 21 铃蟾抗肿瘤活性多肽的提取及其作用机制 的探讨 王冉 国家自然科学基金 2015.1-2017.12 22 构建双靶向稀土上转换纳米探针用于肿瘤 成像与治疗 王旭 国家自然科学基金 2015.1-2017.12 23 以小分子探针研究靶向 PI3K 亚型抑制前列 腺癌转移的作用和多重分子机理 孔德新 国家自然科学基金 2014.1-2017.12 24 双重响应的基金/化疗药物共载时序释放 纳米递送体系靶向抗肝癌研究 王银松 国家自然科学基金 2014.1-2017.12 25 基于调节趋化运动的解毒中药治疗乳腺癌 转移的机制研究 董林毅 国家自然科学基金 2014.1-2016.12 26 基于物理交联的液晶分子印迹色谱固定相 设计、合成及手性药物分离研究 黄艳萍 国家自然科学基金 2014.1-2017.12 27 铂类组蛋白去乙酰化酶抑制剂的设计合 成、活性评价及其靶向作用研究 徐靖源 国家自然科学基金 2014.1-2017.12 28 仿生荧光 DNA 纳米管及其作为药物传递纳 米载体的应用 沈万秋 国家自然科学基金 2014.1-2017.12 29 长余辉纳米探针在淋巴瘤相关 microRNAs 的检测及荧光示踪的应用研究 张毅 国家自然科学基金 2014.1-2016.12 30 先导化合物 Fla-CN 的结构优化、抗糖尿病 作用分子机制及其靶点研究 段宏泉 国家自然科学基金 2014.1-2017.12 31 基于多靶点细胞膜微柱液相色谱技术的黄 精相关复方药效物质及配伍机理研究 唐铖 国家自然科学基金 2014.1-2016.12 32 基于功能性生物材料和靶向递送策略的再 生医学新技术研究 杨志民 国家自然科学基金 2013.8-2018.7 33 以旋覆花内酯活性化合物为探针研究抗哮 喘多重分子作用机制以及先导化合物的发 现 金美花 国家自然科学基金 2013.1-2015.12 34 电子螺旋理论指导下用于 2-氨基-1-芳基 乙醇类手性药物不对称合成的内在手性杯 [4]芳烃催化剂的研究 李韶勇 国家自然科学基金 2013.1-2016.12 1 35 基于 URANT1 靶点的牛尾菜总皂苷抗高尿酸 血症活性成分及作用机制研究 吴晓辉 国家自然科学基金 2013.1-2015.12 36 高选择性蛋白酪氨酸磷酸酶 SHP2 抑制剂的 研究 王润玲 国家自然科学基金 2013.1-2016.12 37 DNA 调控荧光金属纳米团簇应用于乳腺癌 miRNAs 检测 孙艳华 国家自然科学基金 2013.1-2015.12 38 基于 PPARs 多靶点的抗糖尿病药物设计、 合成和活性研究 程先超 国家自然科学基金 2013.1-2015.12 39 含杂环的丙烯酰胺类抗乙肝病毒化合物的 设计、合成与生物活性研究 董卫莉 国家自然科学基金 2012.1-2014.12 40 基于氧化石墨烯的肝靶向小干扰 RNA 和抗 肿瘤药物共载输送体系的研究 杨晓英 国家自然科学基金 2012.1-2014.12 41 基于“血-脑”中有效组分研究酸枣仁解 郁安神整体功效的物质基础及作用机制 乔卫 国家自然科学基金 2012.1-2015.12 42 海绵 jaspis stellifera 中抗类风湿性关 节炎化学成分及作用机制初步研究 唐生安 国家自然科学基金 2012.1-2014.12 项目负责 人 项目 时间 省部级课题 序 号 课题 1 酸枣仁抗抑郁失眠共病显效成分“阿朴菲 型季铵生物碱—黄酮碳苷”的发现及其协 同作用机制研究 乔卫 天津市科委 2017.4-2020.3 2 具有降低肿瘤耐药性及增强免疫识别功能 的多靶标 Pt(IV)前药分子研究 徐靖源 天津市科委 2017.4-2020.3 3 手性生物碱衍生物 ION-31a 抗肿瘤转移作 用靶点研究和结构优化 段宏泉 天津市科委 2017.4-2020.3 4 新型 Pt(IV)类 RNA 聚合酶 I 选择性抑制剂 前药的设计、合成及其抗肿瘤活性研究 乔鑫 天津市科委 2017.4-2020.3 5 细胞膜仿生纳米探针用于β淀粉样肽构象 转换的实时监测 王旭 天津市科委 2017.4-2020.3 6 基于分子印迹的乳癖平消方调控乳腺癌代 谢机制研究 董林毅 天津市科委 2017.4-2020.3 7 可激活吲哚菁绿纳米探针在乳腺癌高选择 性体内成像和靶向释药中的作用及其机制 研究 陈研 天津市科委 2017.4-2020.3 8 选择性 SHP2 突变体 D61G、E76K 抑制剂研 究 王润玲 天津市科委 2016.4-2019.3 9 一口钟抑制 RAFLS 增殖萜-酚加合物成分的 发现及作用机制 唐生安 天津市科委 2016.4-2019.3 10 抗肿瘤转移候选化合物 QN66 的分子作用机 制研究 于阳 天津市科委 2016.4-2019.3 11 基于有序孔道的分子印迹整体柱手性药物 王涎桦 天津市科委 2016.4-2019.3 2 拆分研究 12 胡椒碱与化疗药共载肝靶向纳米体系的构 建及评价 李荣珊 天津市科委 2015.4-2018.3 13 亨氏马尾藻抗 II 型疱疹病毒的药效物质基 础及作用机研究 董彩霞 天津市科委 2015.4-2018.3 14 可激活穿膜肽介导的 CT 对比剂用于肿瘤靶 向成像的研究 杨晓英 天津市科委 2015.4-2018.3 15 用于常温蛋白质距离测量的自旋标记物合 成及其性能研究 刘阳平 天津市科委 2015.4-2018.3 16 酶敏感型靶向系统用于结肠癌基因治疗的 关键技术研究 贺慧宁 天津市科委 2015.4-2018.3 17 EPR/荧光双模态超氧探针的开发及性能研 究 宋玉光 天津市科委 2015.4-2018.3 18 肿瘤细胞特异性蛋白酶小肽底物的细胞水 平筛选研究 孙璐 天津市科委 2015.4-2018.3 19 基于点击化学的抗体定向固定化方法的研 究 徐亮 天津市科委 2014.4-2017.3 20 以 ABLOO 为探针研究其抗哮喘多重分子机 制及协同作用 金美花 天津市科委 2013.4-2016.3 21 新型铂类抗肿瘤配合物的设计合成及其细 胞代谢机制研究 徐靖源 天津市科委 2013.4-2016.3 22 体外移除血液癌细胞的抗体纳米磁球的构 建和应用 杨志民 天津市科委 2012.10-2015.9 23 委陵菜黄酮衍生物的药效学评价和作用机 制研究 乔卫 天津市科委 2012.4-2015.3 24 靶向抑制 PI3K 对前列腺癌转移的影响及机 理研究 孔德新 天津市科委 2012.4-2015.3 25 转筋草抗肿瘤转移生物碱衍生合成及其构 效关系研究 段宏泉 天津市科委 2011.4-2014.3 26 鸡血莲抗前列腺增生活性成分研究及作用 机制研究 吴晓辉 教育部留学回国人 员科研启动基金 2015.8–2018.8 27 熊蜂蜂毒丝氨酸蛋白酶抗血栓作用机制 邱玉玲 教育部留学回国人 员科研启动基金 2014.1-出站 28 以旋覆花内酯活性化合物为探针研究抗哮 喘多重分子作用机制 金美花 博士点新教师 2013.1-2015.12 29 基于神经氨酸酶结构流感病毒抑制剂的计 算机辅助设计、合成及活性研究 王树青 博士点新教师 2012.5-2015.5 30 一口钟抗 RA 萜-酚加合物类成分的发现及 作用机制 唐生安 博士后基金 2016.5-2018.4 31 基于吲哚菁绿的肿瘤靶向组织蛋白酶荧光 探针的研究 陈研 博士后基金 2016.6-2018.7 32 栎瘿酸的抗炎作用及靶点研究 金美花 博士后基金 2016.11-2018.7 33 双模态成像纳米探针用于胶质瘤早期诊断 王旭 博士后基金 2015.11-2017.3 3 及原位疗效评价 34 基于分子印迹微萃取的中药调控乳腺癌代 谢机制研究 董林毅 博士后基金 2015. 8-2018. 7 35 基于 IIB 族离子荧光探针的多孔混金属配 位聚合物的研究 欧阳燕 博士后基金 2014.7-出站 36 熊蜂蜂毒丝氨酸蛋白酶抗血栓作用机制 邱玉玲 博士后基金 2014.6-2016.5 37 铃蟾抗肿瘤小分子多肽的系统鉴定及其抗 肿瘤活性研究 王冉 博士后基金 2014.6-2016.5 38 含硫脲基团氮杂环铂类配合物的抗肿瘤耐 药活性研究 谢承志 39 基于网络多靶点的鸡血莲抗前列腺增生活 性成分研究 吴晓辉 40 基于分子印记的抗癌中药代谢成分机制研 究 董林毅 41 长余辉纳米探针在淋巴瘤相关 miRNAs 的检 测及示踪的应用 张毅 42 寒热两种中药治疗偏头痛的相关研究 滕杰 博士后基金 2013.9-2017.12 43 流感病毒抑制剂的设计合成及活性 王树青 博士后基金 2013.1-2015.1 44 基于网络药理学探索牛尾菜总皂苷多成分 多靶点的整合作用机制 吴晓辉 45 新型多靶点 PPARs 激动剂的设计、合成和 活性研究 程先超 46 细胞膜毛细管色谱筛选消渴中药活性物质 方法的研究 唐铖 47 神经氨酸酶结构靶向抑制剂的计算机辅助 设计、合成及初步活性研究 王树青 48 基于代谢组学的止痛中药吴茱萸的研究 滕杰 博士后基金 博士后基金 2014.2-2015.6 2014.6–2016.6 博士后基金 2014.1-2015.9 博士后基金 2013.7-2015.6 博士后基金 2013.8-2015.8 博士后基金 2012.9-2014.9 博士后基金 2012.7-2014.6 博士后基金 博士后基金 2012.5-2014.3 2011.9-2014.12 课题获奖一览表 序号 题目 姓名 获奖名称 年度 1 胶原-多糖基功能性生物医用材 料的基础研究 王银松 天津市自然科学奖二等奖 2014 4 发表论文情况一览表 序号 1 通讯作者/ 发表杂志及 第一作者 出版时间 陈研 Journal of Applied Polymer Science, 2014 Sep 15;131(18) 文章名称 Temperature-Triggered Disintegrable Poly(N-isopropylacrylamide) Nanoparticles via Heterophase Polymerization in the Presence of Tetramethylethylenediamine and Sodium Dodecyl Sulfate 2 Thermoresponsive ketoprofen-imprinted monolith prepared in ionic liquid 刘照胜 Analytical and Bioanalytical Chemistry, 2014, 406, 5359-5367 3 Biological evaluation of a cytotoxic 2-substituted benzimidazole copper(II) complex: DNA damage,antiproliferation and apoptotic induction activity in human cervical cancer cells 徐靖源 Biometals, 2014，27， 155-172 4 In vitro multifaceted activities of a specific group of novel phosphatidylinositol 3-kinase inhibitors on hotspot mutant PIK3CA. 孔德新 Invest New Drugs. 2014, 32 (6): 1134-1143. 5 Inhibitory Effects of JEUD-38, a New Sesquiterpene Lactone from Inula japonica Thunb, on LPS-Induced iNOS Expression in RAW264.7 Cells 孔德新 金美花 Inflammation. 2014, 2015;38(3):941-8. 6 AS252424, a PI3K Inflammatory Responsiveness in Mouse Bone Marrow-Derived Mast Cells. 孔德新 Inflammation, 2014, 37: 1254-1260. 7 Cell-Penetrating Peptides Meditated Encapsulation of Protein Therapeutics into Intact Red Blood Cells and its Application. 杨志民 Journal of Controlled Release， 2014, 176: pp123-132 8 Low molecular weight protamine (LMWP): a nontoxic protamine substitute and an effective cell-penetrating peptide. 杨志民 Journal of Controlled Release， 2014, 193: pp63–73. 9 Nuclease activity and protein-binding properties of a novel tetranuclear thiosemicarbazide Pt(II) complex 徐靖源 Dalton Trans.2014， 43，1663-1671 10 Two polypyridyl copper(II) complexes: synthesis,crystal structure and interaction with DNA and serum protein in vitro 徐靖源 New J. Chem. 2014， 38，955-965 11 Anti-inflammatory terpenes from flowers of Inula japonica 金美花 Planta Med. 2014 ;80(7):583-9 12 Syntheses, Crystal Structures, and DNA Bindings of Co(III) and Ni(II) Complexes Based on 徐靖源 谢承志 Synthesis and Reactivity in 5 I 2,6-Bis(benzimidazol-2-yl)-4-hydroxypyridine Ligand. Inorganic, Metal-Organic, and Nano-Metal Chemistry,2014，44， 1175-1182 13 Molecular cloning of a novel tryptophyllin peptide from the skin of the orange-legged monkey frog, Phyllomedusa hypochondrialis 王冉 Chem Biol Drug Des. 2014；83(6):731-40. 14 In vitro Antitumor Activity of Stellettin B, a Triterpene from Marine Sponge Jaspis stellifera, on Human Glioblastoma Cancer SF295 Cells. 孔德新 Mar Drugs. 2014, 12: 4200-4213. 15 Thiosemicarbazone Cu(II) and Zn(II) complexes as potential anticancer agents: Syntheses, crystal structure, DNA cleavage, cytotoxicity and apoptosis induction activity 徐靖源 Journal of Inorganic Biochemistry,2014， 136，13-23 16 Construction of supramolecular nanofibers through electrostatic interaction between perylene and cholesterol derivatives 段宏泉 Chinese Chemical Letters，Volume 25, Issue 1, January 2014, 51-54; 17 Anti-inflammatory Terpenes from Flowers of Inula Japonica 金美花 段宏泉 Planta Medica，2014, 80, 583-589. 18 Antitumor metastasis pregnane alkaloids from Pachysandra terminalis 段宏泉 J Asian Nat Prod Res， 2014;16(5): 440-6 19 Synthesis and Antitumor Invasive Activity of Novel Ionone Alkaloid Derivatives 段宏泉 Letters in Drug Design & Discovery， 2014, 11:395-402 20 Synthesis and Antimetastatic Effects of E-Salignone Amide Derivatives 段宏泉 Drug Dev Res，2014 Mar;75(2):76-87 21 Jaspiferins C–F, four new isomalabaricane-type triterpenoids from the South China Sea sponge Jaspis stellifera 唐生安 Journal of Asian Natural Products Research，2014, 16 (5), 427-433 22 Novel polyhydroxylated steroids from the East China Sea gorgonian Echinogorgia sassapo reticulata with suppressive activity of leukotriene C4 generation and degranulation in bone marrow-derived mast cells 唐生安 Journal of Asian Natural Products Research，2014, 16 (4), 351-357 23 A New Aurone from Smilax riparia 唐生安 段宏泉 Chemistry of Natural Compounds，2014 ,50 (6), 989-993 24 Synthesis and Antimetastatic Effect of E -salignone 段宏泉 Chemistry of Natural Compounds , 2014 , 50 (4) :697-701 6 25 Synthesis of imprinted monolithic column with high content of monomers in ionic liquid 黄艳萍 RSC Advances, 2014, 4, 50662-50667 26 Preparation and characterization of lysine-immobilized poly(glycidyl methacrylate) nanoparticle-coated capillary for the separation of amino acids by open tubular capillary electrochromatography 徐亮 Journal of Chromatography A. 2014 Jan 3;1323:179-83. 27 Synthesis, characterization and application of organic-inorganic hybrid and carbaryl-imprinted capillary monolithic column 徐亮 Chemical Research in Chinese Universities 2014 , 30 (3) :374-378 28 Developmental and cartilaginous effects of protein-coated SiO2 nanoparticle corona complexes on zebrafish larvae. 张瑶纾 RSC Advances 2014 May; 4(36):18541-18548. 29 Identification of nuclear factor-κB inhibitors and β2 adrenergic receptor agonists in Chinese medicinal preparation Fuzilizhong pills using UPLC with quadrupole time-of-flight MS. 董林毅 Phytochem Anal 2014 Mar-Apr; 25(2): 113-21. 30 A hematoporphyrin-based delivery system for drug resistance reversal and tumor ablation 王银松 Biomaterials. 2014 Mar;35(8):2462-70. 31 N-lauroyl chitosan surface-modified PLGA nanoparticles as carrier for adriamycin to overcome cancer drug resistance 王银松 Journal of Microencapsulation. 2014;31(3):203-10. 32 pH-sensitive pullulan-based nanoparticles for intracellular drug delivery 王银松 Polymer Chemistry,2014;111: 908-17. 33 Investigating the cellular fate of a DNA-targeted platinum-based anticancer agent by orthogonal double-click chemistry. 34 pH-sensitive pullulan-based nanoparticle carrier for adriamycin toovercome drug-resistance of cancer cells 乔鑫 J. Biol. Inorg. Chem.19 (2014) 415-426. 王银松 Carbohydrate Polymers, 2014 , 111 (20) :908-917 王银松 ACS Applied Materials & Interfaces, 2014 , 6 (21) :18712-18720 36 Qualitative analysis of the helical electronic energy of inherently chiral calix[4]arenes: an approach to effectively assign their absolute configuration 李韶勇 International Journal of Molecular Sciences，2014, 15(6), 9844-9858。 37 Fluorescent calix[4]arene chemosensor for acidic and basic amino acids in pure aqueous media 李韶勇 RSC Advances, 2014, 4, 28046–28051. 38 The derivatives of oseltamivir design passing through the important cleft of neuraminidase 王树青 王润玲 Molecular Simulation2014, 35 Core-shell nanoparticles based on pullulan and poly(β-amino) ester for hepatoma-targeted codelivery of gene and chemotherapy agent 7 against influenza virus by de novo design 40(15): 1209–1217 39 Design Potential Selective Inhibitors for Treating Cancer by Targeting the Src Homology 2 (SH2) Domain-Containing Phosphatase 2 (Shp2) with Core Hopping Approach 王润玲 Protein & Peptide Letters, 2014 ;21(6):556-63. 40 The Discovery of a Novel and Selective Inhibitor ofPTP1B Over TCPTP: 3D QSAR PharmacophoreModeling, Virtual Screening, Synthesis, andBiological Evaluation 王润玲 Chem Biol Drug Des, 2014 , 83 (6) :697 41 Identification of novel multitargeted PPARα/γ/δ pan agonists by core hopping of rosiglitazone 程先超 王润玲 Drug Design Development and Therapy, 2014 , 8 (default) :2255-2262 周晶 Journal of Asian Natural Products Research. 2014, 16 （5）： 527-534 王润玲 Molecular Simulation, 2014 , 40 (12) :904-911 42 Synthesis and biological evaluation of novel podophyllotoxin analogs as antitumor agents 43 Designofspeci cinhibitorsoftheproteintyrosinephosphataseSHP2byvirtualscreeningand Corehoppingmethod 44 SAHA-based novel HDAC inhibitor design by core hopping method 程先超 王润玲 Journal of Molecular Graphics and Modelling, 2014 , 54 :10-18 45 Preparation of reduction-triggered degradable microcapsules for intracellular delivery of anti-cancer drug and gene 杨晓英 Polymer, 2014, 55, 110-118 46 Folic acid-conjugated pH/temperature/redox multi-stimuli responsive polymer microspheres for delivery of anti-cancer drug 杨晓英 Journal of Colloid and Interface Science, 2014, 429, 34-44 杨志民 Journal of Biomedical Materials Research Part A,102:575-587 (2014). 杨志民 Pharmaceutical Research,31:579-592 (2014). 47 Cell-penetrating peptides: Achievements and challenges in application for cancer treatment. 48 Magnetic Targeting of Novel Heparinized Iron Oxide Nanoparticles Evaluated in a 9L-glioma Mouse Model. 49 Protease-Activatable Hybrid Nanoprobe for Tumor Imaging. . 杨志民 Advanced Functional Materials,24:5443-5 453 (2014) 50 The synergetic antibacterial activity of Ag 张毅 Journal of Inorganic 8 51 islands on ZnO (Ag/ZnO) heterostructure nanoparticles and its mode of action Biochemistry，2014, 130, 74-83 Low-molecular-weight protamine-modified PLGA nanoparticles for overcoming drug-resistant breast cancer. 杨志民 Journal of Controlled Release,192:47-56 (2014). 沈万秋 Journal of Biomedical Nanotechnology， 2014,10（9） ： 2350-2370 周晔 Spectroscopy and Spectral Analysis, 2014（34）9，2419-2423 52 DNA Nanotechnology and Its Applications in Biomedical Research 53 Identification of Some Piper Crude Drugs Based on Fourier Transform Infrared Spectrometry 54 Different Places by HPLC·—ESI—-M S and FTIR M ethods 贺慧宁 杨志民 Current Pharmaceutical Biotechnology，2014, 15(3): pp240-255. 55 Highly sensitive free radical detection by nitrone functionalized gold nanoparticles 刘阳平 Nanoscale, 2014 , 6 (3) :1646-1652 56 Characterization of the binding of the Finland trityl radical with bovine serum albumin 刘阳平 RSC Advances, 2014 , 4 (88) :47649-47656 57 Smilax riparia reduces hyperuricemia in mice as a potential treatment of gout 吴晓辉 Am J Chin Med 2014; 42(1): 257-9 58 Riparoside B and timosaponin J, two steroidal glycosides from Smilax riparia, resist to hyperuricemia based on URAT1 in hyperuricemic mice 吴晓辉 Phytomedicine 2014; 21(10): 1196-201 59 Effects of Smilaxchinoside A and Smilaxchinoside C, Two Steroidal Glycosides from Smilax riparia, on Hyperuricemia in a Mouse Model 吴晓辉 Phytother Res 2014; 28(12): 1822-8 60 Pallidifloside D, a saponin glycoside constituent from Smilax riparia, resist to hyperuricemia based on URAT1 and GLUT9 in hyperuricemic mice 吴晓辉 J Ethnopharmacol 2014; 157: 201-5 61 Supermacroporous polymer monolith prepared with polymeric porogens via viscoelastic phase separation for capillary electrochromatography 刘照胜 Journal of Chromatography A, 2014, 1369, 170-180 62 Synthesis, Crystal Structure, Magnetic Property and DFT Study of a Novel 2D Polymer [Cu(pdc)(bpy)]•H2O. 谢承志 Chinese J. Struct. Chem, 2014 , 33 (2) :270-276 徐靖源 Journal of Coordination Chemistry, 2015 , 68 (2) :277-294 63 A thiosemicarbazone copper(II) complex as a potential anticancer agent. 9 64 Synthesis, biological evaluation and 3D-QSAR studies of imidazolidine-2,4-dione derivatives as novel protein tyrosine phosphatase 1B inhibitors 65 Efficient Dynamic Nuclear Polarization at 800 MHz/527 GHz with Trityl-Nitroxide Biradicals 刘阳平 Angew. Chem. Int. Ed., 2015, 54, 11770-4 66 Site-Specific Detection of Free Radicals in Membranes Using an Amphiphilic Spin Trap 刘阳平 Appl. Magn. Reson. 2015, 46, 489-504 67 Functionalized Graphene Oxide with Hepatocyte Targeting as Anti-Tumor Drug and Gene Intracellular Transporters 杨晓英 Journal of Nanoscience and Nanotechnology, 2015 , 15 (3) :2052-9 68 Enhanced Electrochemical Oxidation of p-Nitrophenol Using Single-Walled Carbon Nanotubes/Silver Nanowires Hybrids Modified Electrodes 杨晓英 Journal of Nanoscience and Nanotechnology, 2015 , 15 (8) :6078-81 69 Synthesis and anti-metastatic effects of novel chiral ionone alkaloid derivatives 段宏泉 European Journal of Medicinal Chemistry 101 (2015) 唐生安 段宏泉 Journal of Asian Natural Products Research 2015， 17(2) 段宏泉 Chemistry of Natural Compounds 2015, 51(2) 段宏泉 Natural Product Research, 2016 , 30 (17) :1988-1992 段宏泉 European Journal of Pharmaceutical Sciences, 2016 , 82 (1) :52-63 唐生安 Chemistry of Natural Compounds 2015 ,51 (2), 232-235 程先超 王润玲 European Journal of Medicinal Chemistry, 2015, 103, 91-104. 70 Three new polyunsaturated lipids from a Guangxi marine sponge Haliclona sp. 71 A NEW MEGASTIGMANE ALKALOID FROM Pachysandra terminalis WITH ANTITUMOR METASTASIS EFFECT 72 Flavonoid derivative exerts an antidiabetic effect via AMPK activation in diet-induced obesity mice 73 Anti-obesity and anti-diabetic effects of flavonoid derivative (Fla-CN) via MicroRNA in hight fat diet induced obesity mice 74 Penangianol A and B: Two New Norlgnans from Rhizomes of Abacopteris penangiana 75 Cell-penetrating peptides: Achievements and challenges in application for cancer treatment 杨志民 J Biomed Mater Res Part A, 2014, 102A:575-587 76 PTD-Modified ATTEMPTS for Enhanced Toxin-based Cancer Therapy: An In Vivo Proof-of-Concept Study. 杨志民 Pharm Res, 2015, 32:2690-2703 10 杨志民 J Biomed Mater Res Part A, 2015， 103A:409-419. 王银松 International Journal of Pharmaceutics, 2015, 483: 89–100 79 Lactosylated PLGA nanoparticles containing e-polylysine for the sustained release and liver-targeted delivery of the negatively charged proteins 王银松 International Journal of Pharmaceutics, 2015, 478: 633–643 80 15 Years of ATTEMPTS: A Macromolecular Drug Delivery System Based on the CPP-Mediated Intracellular Drug Delivery and Antibody Targeting 贺慧宁 杨志民 Journal of Controlled Release， 2015, 205: pp58–69 81 A folate modified pH sensitive targeted polymeric micelle alleviated systemic toxicity of doxorubicin (DOX) in multi-drug resistant tumor bearing mice 高薇 European Journal of Pharmaceutical Sciences, 2015（76）： 95–101 82 Enzyme-Triggered, Cell Penetrating Peptide-Mediated Delivery of Anti-Tumor Agents 杨志民 Journal of Controlled Release, 2015 , 240 :67 83 Water-compatible molecularly imprinted polymers prepared using metal–organic gel as porogen 黄艳萍 RSC Advances，2015, 5, 84601-84609 84 Macromolecular crowding of molecular imprinting: A facile pathway to produce drug delivery devices for zero-order sustained release 黄艳萍 International Journal of Pharmaceutics，2015， 496，822-833 刘照胜 黄艳萍 Analytical and Bioanalytical Chemistry. 2015, 407:2923-2931. 黄艳萍 Chromatographia, 2015, 78 (15), 995-1003. 77 Recombinant TAT-gelonin fusion toxin: Synthesis and characterization of heparin/protamine-regulated cell transduction. 78 A polymeric prodrug of cisplatin based on pullulan for the targeted therapy against hepatocellular carcinoma 85 Macromolecular crowding-assisted fabrication of liquid-crystalline imprinted polymers. 86 Separation of epigallocatechin gallate from natural plant extracts using crowding agents-assisted imprinted polymers 87 Synthesis of monodisperse molecularly imprinted microspheres with multi-recognition ability via precipitation polymerization for the selective extraction of cyromazine, melamine, triamterene and trimethoprim 刘照胜 Journal of Chromatography B, 2015, 1007, 127-131 88 Molecular crowding-based imprinted monolithic column for capillary electrochromatography. 刘照胜 Electrophoresis. 2015, 36, 818-824 89 Comparison of multi-recognition molecularly 刘照胜 Analytical and 11 imprinted polymers for recognition of melamine, cyromazine, triamterene, and trimethoprim Bioanalytical Chemistry, 2015, 407(23), 7145-7155 刘照胜 Journal of Chromatography A, 2015, 1425, 180-188. 91 Novel polystyrene/antibody nanoparticle-coated capillary for immunoaffinity in-tube solid-phase microextraction 徐亮 Analytical and Bioanalytical Chemistry,2015,407: 2771-2775 92 Inhibitory effects of JEUD-38, a new sesquiterpene lactone from Inula japonica Thunb, on LPS-induced iNOS expression in RAW264.7 cells. 孔德新 金美花 Inflammation, 2015 , 38 (3) :1-8 93 IVSE, isolated from Inula japonica, suppresses LPS-induced NO production via NF-kB and MAPK inactivation in RAW264.7 cells. 孔德新 金美花 Life Sci, 2015 , 124 :8-15 94 Identification and Functional Analysis of a Novel Tryptophyllin Peptide from the Skin of the Red-eye Leaf Frog, Agalychnis callidryas. 王冉 Int. 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Chem. 2017, 82, 588-596 182 Gold Nanorods with Silica Shell and PAMAM Dendrimers for Efficient Photothermal Therapy and Low Toxic Codelivery of Anticancer Drug and siRNA 杨晓英 Advanced Materials Interfaces，2017， 1701166（1-9） 183 Solvent-responsive floating liquid crystalline-molecularly imprinted polymers for gastroretentive controlled drug release system 黄艳萍 International Journal of Pharmaceutics, 2017, 532, 365-373 184 PEGylated doxorubicin nanoparticles mediated by HN-1 peptide for targeted treatment of oral squamous cell carcinoma 王银松 International Journal of Pharmaceutics, 2017, 525: 21–31 185 Thiol-Dependent Reduction of the Triester and Triamide Derivatives of Finland Trityl Radical Triggers O2-Dependent Superoxide Production 刘阳平 宋玉光 Chem. Res. 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Antagonists 程先超 Letters in Drug Design & Discovery, 2017, 14, 959-973. 彭超 刘阳平 CHEMICAL JOURNAL OF CHINESE UNIVERSITIES， 2017,38 （9）:1542~1548 宋玉光 CHEMICAL JOURNAL OF CHINESE UNIVERSITIES，2017, 38(8):1354-1361 唐生安 Chemistry of Natural Compounds, 2017, 53(2), 325-327. 214 Novel Fluorescent/EPR Difunctional Probe for Detecting Hypochlorite 215 Characterization of the Interaction Between Esterified TAM Radical and Bovine Serum Albumin 216 Axinellin A and B: Two New Pyrrolactam Alkaloids from Axinella sp. 21 217 Synthesis and Insecticidal, Anticancer Activity of Novel Pyrazole Acyl Urea Derivatives 董卫莉 J.Chem.Soc.Pak 39（3）：464-470 218 抗糖尿病先导化合物 Fla-CN 的合成工艺研究 段宏泉 天津医科大学学报， 2014, 20(1): 68-70 219 LC-MS/MS 测定血浆中委陵菜黄酮衍生物(Fla-CN) 浓 度及其在大鼠药动学研究中的应用 段宏泉 中国药学杂志， 2014,49（10） ，869-873 220 蒲公英水煎剂联合委陵菜黄酮灌胃对糖尿病小鼠血糖 #血脂水平的影响 段宏泉 山东医药，2014，54 （11），29-31 221 旋覆花中化学成分及其活性研究 唐生安 中国中药杂志，2014， 39 (1)，83-88 222 中国南海海绵 Jaspis stellifera 中异臭椿型萜类成 分研究 唐生安 天津医科大学学报， 2014, 20 (5), 357-359 223 活细胞内人 AGTR1-3'UTR 的荧光标记及应激定位分析 张毅 中国细胞生物学学报， 2014, 36(5), 631-637 224 活细胞内以光漂白荧光损失（FLIP）技术分析 HuR 蛋 白的应激动力学行为 张毅 中国细胞生物学学报， 2014，36(9), 1235-1240 225 旋覆花中化学成分及其活性研究 金美花 中国中药杂志, 2014, 39(1):83-88 226 九龙化风丸中升麻素苷、5-O-甲基维斯斯阿米醇苷、 羌活醇、异欧前胡素和细辛脂素的 HPLC 梯度洗脱法测 定 房志仲 中成药，2014,36（3） ： 541-546 227 星点设计-效应面积法优化硝苯地平分散片处方 房志仲 医大学报，2014,20 （4）：323-327 228 复方奥美拉唑胶囊质量控制方法的研究 房志仲 医大学报，2014,20 （3）：243-246 229 环索奈德鼻用凝胶剂制备及质量控制 房志仲 医大学报，2014,20 （5）：408-498 230 复方更昔洛韦眼用凝胶剂的制备及质量控制 房志仲 医大学报，2014,20 （6）：490-410 231 酸枣仁合欢方质量控制方法及其皂苷部位指纹图谱研 究 乔卫 中药材，2014, 37(1):126-129. 232 新型委陵菜黄酮衍生物对四氧嘧啶诱导糖尿病小鼠血 糖血脂的影响 乔卫 天津医科大学学报， 2014, 20(3):169-171 233 酸枣仁合欢方提取物中( － ) -丁香树脂酚 -4-O-β-D-呋喃芹糖基-( 1→2) -β-D-吡喃葡萄糖苷 含量的反相高效液相色谱法测定 乔卫 时珍国医国药，2014， 25（9）：2065-2067 234 酶解辅助提取金芪降糖片中生物碱的工艺研究 周晶 中成药，2014,36（1） ： 194-197 235 坎地沙坦酯片溶出度考察 刘照胜 天津医科大学学报， 2014，20（3） ，247-251 236 临床药师的工作内容与素质能力的调查 颜久兴 沈阳药科大学学报， 2014,3（11） 237 佐剂性关节炎大鼠的血常规 于飞 中国比较医学杂志， 22 2014,1(24)：5-7 238 HPLC-DAD 法同时测定酸枣仁皂苷中酸枣仁皂苷 A、B 和白桦脂酸、白桦脂醇 乔卫 中成药，2015, 37(5): 1013-1016 239 酸枣仁合欢方提取物中酸枣仁皂苷 A 量的 HPLC-ELSD 法同时测定 乔卫 时珍国医国药，2015, 26(8): 1796-1798 240 大株红景天的化学成分及体外抗肿瘤转移活性研究 段宏泉 中国中药杂志 2015，40（2） 241 三黄消渴汤对胰岛素抵抗 3T3-L1 脂肪细胞的影响 唐铖 时珍国医国药 2015， 26(3):560-562 242 基于细胞膜毛细管色谱技术的黄连活性物质研究方法 的探索 唐铖 时珍国医国药 2015, 26(9):2258-2260 243 中国南海海绵 Haliclona sp.中化学成分的研究 唐生安 天津医科大学学报 2015, 21(5), 385-387 244 中国南海海绵 Axinella sp.中化学成分的研究 唐生安 天津医科大学学报 2015, 21 (3), 217-219 245 UPLC-Q-TOF-MS 法同时测定平消片中 7 种成分. 董林毅 中草药.2015，46（11） ： 1625-1628. 246 超高效液相色谱质谱联用技术同时测定小金丸中 7 种 成分的含量. 董林毅 中国药学杂志.2015， 50（8）：718-721. 247 4－氨基氨替比林分光光度法测定苯酚滴耳液中苯酚 含量 房志仲 医大学报，2015， 21(1)：87-89 248 氯霉素凝胶剂的制备与质量标准研究 房志仲 医大学报，2015， 21(5)：446-448 249 基于纳米粒子的 TR-FRET 传感器用于 miRNAs 的无扩增 检测 张毅 天津医科大学学报， 2015，21(6)：521-529 250 基于高效液相色谱-质谱联用技术的黄精化学成分快 速鉴别研究 唐铖 时珍国医国药 2016(4): 794-796 251 不同给药介质对大鼠口服胡椒碱的药动学和生物利用 度的影响 李荣珊 南开大学学报（自然科 学版）,49(3):105-111 252 白胡椒化学成分研究 唐生安 天津医科大学学报， 2016，22（4） ，300-301 253 解郁舒心制备工艺与质量分析 乔卫 中国实验方剂学， 2016,22（2） ：6-9 段宏泉 天津医科大学学报， 2016，22 （2）： 119-125. 254 大株红景天化学成分的研究 255 红景天注射液 HPLC 指纹图谱研究 段宏泉 天津医科大学学报， 2016，22 （2）： 164-167. 256 新型含吡啶基吡唑酰胺类化合物的合成与抗肿瘤活性 董卫莉 天津医科大学学报， 2016，22（2） ：115-118 257 复方阿托伐他汀钙依折麦布胶囊的质量控制 房志仲 天津医科大学学报， 2016,22（1） 23 258 复方呋塞米螺内酯胶囊质量控制方法的研究 房志仲 天津医科大学学报， 2016,22（1） 259 HPLC 法测定黄丹兰颗粒剂中苦参碱和氧化苦参碱含量 房志仲 天津医科大学学报， 2016,22（5） 260 星点设计-效应面法优化枸橼酸西地那非分散片处方 房志仲 天津医科大学学报， 2017，23(1): 41-45. 261 酸枣仁黄酮 HPLC 指纹图谱建立及 2 种成分测定 乔卫 中成药， 2017,39(5):989-992 262 高效液相色谱法测定盐酸多奈哌齐分散片中的药物含 量 房志仲 天津医科大学学报， 2017，23(6):566-569 263 复方阿托伐他汀钙与依折麦布胶囊剂的处方优化研究 房志仲 天津医科大学学报， 2017. 23 (5):469-474 264 HPLC-DAD 法同时测定 SHF 抗抑郁皂苷部位中 5 个指标 成分含量 乔卫 天津医科大学学报， 2017 ,23 (5 ):464-468 265 羧甲基-β-环糊精用于氢化安息香和联萘酚磷酸酯的 毛细管电泳拆分 冉瑞雪 南开大学学报(自然科 学版), 2017(1):59-63. 266 酸枣仁合欢方中 5 个皂苷成分含量的高效液相-二极管 阵列法同时测定 乔卫 时珍国医国药， 2017 ,28 (5):1069-1071 24 出版教材、科研专著一览表 序号 姓名 题目 出版单位 时间 主编或参编 1 吕伟 《有机化学学习指导》 2016 参编 2 姜炜 有机化学 高等教育出版社 高等教育出版社 2015 副主编 3 姜炜 姜炜 5 姜炜 6 曹海燕 7 曹海燕 8 吕伟 9 张毅 10 陈正华 11 姜炜 12 曹海燕 13 陈正华 高等教育出版社 北京大学医学出版社 高等教育出版社 高等教育出版社 高等教育出版社 高等教育出版社 山东人民出版社 高等教育出版社 高等教育出版社 高等教育出版社 自编 2015 2015 2014 2015 2014 2015 2015 2014 2014 2014 2014 参编 4 有机化学学习解析 有机化学 医学化学学习指导 医用化学实验 医学化学学习指导 有机化学 仪器分析实验 基础化学习题解析 医学化学 医学化学 基础化学习题解析 14 曹海燕 刘景英 张竹 医用化学实验报告册 自编 2014 主编 15 周晔 周晔 17 周晔 中国医药科技出版社 人民卫生出版社 中国医药科技出版社 2016 2016 2015 主编 16 中医药学概要 《生药学》第 7 版 《生药学》第 3 版 18 周晔 张骏 人民卫生出版社 2014 参编 19 颜久兴 颜久兴 21 颜久兴 22 朱学慧 23 王润玲 24 程先超 科学出版社 科学出版社 化学工业出版社 人民卫生出版社 人民卫生出版社 中国医药科技出版社 2016 2016 2017 2015 2016 2016 副主编 20 药事管理学（第 4 版） 医药企业管理 药事管理学（第 3 版） 临床药物治疗学总论 药物化学 药物设计学 25 于丽 谢承志 无机化学（第 3 版） 人民卫生出版社 2015 于丽 于丽欧 阳燕 徐靖源 徐靖源 宋玉光 欧阳燕 郑超 郑超 基础化学（第 3 版） 基础化学学习指导与习 题解析 无机化学 无机化学学习指导 仪器分析 基础化学实验 物理化学 无机化学学习指导 高等教育出版社 2014 高等教育出版社 2014 人民卫生出版社 人民卫生出版社 中国医药科技出版社 高等教育出版社 人民卫生出版社 人民卫生出版社 2016 2016 2016 2016 2017 2015 26 27 28 29 30 31 32 33 临床药理学 25 参编 参编 主编 参编 参编 参编 参编 参编 参编 主编 参编 参编 参编 副主编 参编 参编 参编 参编 参编 参编 主编 主编 参编 参编 参编 参编 获得专利一览表 序号 姓名 专利名称 时间 1 2 3 4 5 段宏泉 段宏泉 段宏泉 黄艳萍 程先超 2014.11 2014.8 2014.4 2014.11 2014.5 6 程先超 7 王润玲 8 杨晓英 9 乔卫 10 段宏泉 11 段宏泉 12 徐靖源 13 黄艳萍 14 刘照胜 刘照胜 一种黄酮类似物、制备及其作为抗糖尿病药物的用途 黄酮衍生物、制备方法及其医药用途 一种抗肿瘤转移作用的转筋草生物碱类化合物 以聚苯乙烯为致孔剂的超大孔毛细管整体柱的制备方法 L-酪氨酸类衍生物及其药物组合物与应用（发明专利） 5-取代苄亚甲基咪唑烷-2,4-二酮类衍生物及其应用（发 明专利） 5-取代亚甲基咪唑烷-2,4-二酮类衍生物及其药物组合 物与应用 靶向性抗肿瘤药物和基因共载载体材料及制备和应用 （发明专利） 酸枣仁生物碱单体成分酸李碱及其制备方法与应用（发 明专利） 黄酮衍生物、制备方法及其医药用途 PCT/CN/2010/001818（国际发明专利美国专利授权） 黄酮衍生物、制备方法及其医药用途 PCT/CN/2010/001818（国际发明专利日本专利授权） 基于螯合诱导荧光增强的锌离子荧光探针及其应用 金属-有机凝胶为致孔剂的分子印迹控释药物载体的制 备(发明专利) 西替利嗪分子印迹整体柱及其制备方法（发明专利） 一种手性分子作为掺杂剂制备液晶分子印迹整体柱的方 法（发明专利） 高单体含量的分子印迹整体柱与制备方法（发明专利） 漂浮缓释型胃内滞留液晶分子印迹药物载体及其制备 金属离子为桥接剂的 18β-甘草次酸分子印迹聚合物和 整体柱 电荷翻转普鲁兰多糖衍生物及其合成方法和用途 15 16 17 刘照胜 刘照胜 18 刘照胜 19 王银松 26 2014.5 2014.8 2015.1 2015.11 2015.2 2015.2 2015.11 2016.8 2016.4 2016.3 2016.2 2017.4 2017.7 2017.11