15.学生发表论文及专利.pdf
15、 学生发表论文、参加 会议及授权专利 179 Author's personal copy Applied Surface Science 285P (2013) 840–845 Contents lists available at ScienceDirect Applied Surface Science journal homepage: www.elsevier.com/locate/apsusc Hydrothermal synthesis of CdS nanoparticle/functionalized graphene sheet nanocomposites for visible-light photocatalytic degradation of methyl orange Shancheng Yan a,b,∗ , Bojun Wang a , Yi Shi b , Fan Yang a , Dong Hu a , Xin Xu a , Jiansheng Wu a a b School of Geography and Biological Information, Nanjing University of Posts and Telecommunications, Nanjing 210046, PR China National Laboratory of Solid State Microstructures, School of Electronic Science and Engineering, Nanjing University, Nanjing 210093, PR China a r t i c l e i n f o Article history: Received 11 July 2013 Received in revised form 30 August 2013 Accepted 31 August 2013 Available online 8 September 2013 Keywords: Functionalized graphene sheets Cadmium sulfide Methyl orange Photodegradation property a b s t r a c t CdS nanoparticle/functionalized graphene sheet (CdS NP/FGS) nanocomposites were successfully prepared in a one-step hydrothermal synthesis route. The samples were characterized by field emission scanning electron microscopy, transmission electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, photoluminescence spectroscopy, and Raman spectroscopy. In addition, the photocatalytic performance of CdS NP/FGS composites and pure CdS in the degradation of methyl orange (MO) was examined using visible light. Results show that the addition of FGS can enhance the photocatalytic performance of CdS NP/FGS composites with a maximum degradation efficiency of 98.1% under visible light irradiation as compared with pure CdS (60.1%). This finding can be attributed to three reasons. First is the strong redox ability of CdS in the nanocomposite with smaller crystal size. Second is the increase in specific surface area for more adsorbed MO. Third is the reduction in electron–hole pair recombination with the introduction of FGS. Based on their high photocatalytic activity, the CdS NP/FGS composites can be expected to be a practical visible light photocatalyst. © 2013 Elsevier B.V. All rights reserved. 1. Introduction Semiconductor quantum dots are quasi-zero-dimensional materials that have gained considerable research interest in the past decade because of their unique size- and shape-dependent properties. Among these materials, CdS is an important II–VI semiconductor because it can be potentially applied in many fields, such as in light-emitting diodes, thin-film transistors, solar cells, photocatalysts, etc. [1–5]. The narrower band gap of CdS (2.42 eV) than that of TiO2 (3.2 eV) facilitates the utilization of visible light, making CdS a competitive photocatalyst candidate [6,7]. When CdS is irradiated by visible light, electrons located in the valence band can be excited to the conduction band, forming electron–hole pairs that are responsible for photocatalytic activity. However, the rapid recombination of the excited electron–hole pairs is an obstacle limiting the photocatalytic activity of catalysts. One way to delay the recombination of these electron–hole pairs is the hybridization of CdS with other materials, such as conductive polymer films [8], ∗ Corresponding author at: School of Geography and Biological Information, Nanjing University of Posts and Telecommunications, Nanjing 210046, PR China. Tel.: +86 25 85866634; fax: +86 25 85866634. E-mail address: yansc@njupt.edu.cn (S. Yan). carbon nanotubes [9], and graphene [10–12], which have promising catalyst applications. Graphene, as a new two-dimensional carbon nanomaterial, has received increasing attention in recent years because of its outstanding physical and chemical properties and excellent electrocatalytic ability [13–19]. When semiconductor nanoparticles are incorporated into matrices, graphene can remarkably improve the properties of these host materials [20–25]. When graphene is added into CdS, photogenerated electrons of CdS can transfer from the conduction band to graphene by a percolation mechanism, where graphene serves as an electron acceptor and effectively suppresses the electron–hole pair recombination. Moreover, the excellent electron conductivity of graphene can carry out the rapid transport of charge carriers and subsequent effective charge separation. Therefore, the photocatalytic performance of CdS nanoparticle/functionalized graphene sheet (NP/FGS) has attained effective enhancement. Graphene-based nanocomposites clearly exhibit superior performance to pure host materials in practical fabrication. As a new type of nanocomposite material, these nanocomposites have been widely used in some optoelectronic and photodegradation applications. In this study, we report a novel, facile, one-step synthetic route for CdS NP/FGS nanocomposites with promising photodegradation properties. The synthetic route is illustrated in Scheme 1. The novel route for the fabrication of CdS NP/FGS nanocomposites was 0169-4332/$ – see front matter © 2013 Elsevier B.V. All rights reserved. http://dx.doi.org/10.1016/j.apsusc.2013.08.138 180 Advanced Materials Research Vols. 887-888 (2014) pp 174-180 © (2014) Trans Tech Publications, Switzerland doi:10.4028/www.scientific.net/AMR.887-888.174 Reliable solvothermal growth of diverse heterostructures based on CdS nanowires Fan Yanga, Shancheng Yanb*, Bojun Wangc, Zhenhua Shuaid, Mingxia Zhange School of Geography and Biological Information, Nanjing University of Posts and Telecommunications, Nanjing 210023, China; a b c d yf3430370@126.com, yansc@njupt.edu.cn, wongbj@163.com, 673166450@qq.com, e 936524858@qq.com Keywords: Heterostructure, Growth Mechanism, Cadmium Sulfide, Semiconductor Abstract: In the present study, the heterostructures of ZnO Nanoparticle (NP)/CdS nanowire (NW), SnO2NP/CdS NW, NiS NP/CdS NW, FeS NP/CdS NW, Ag2S NP/CdS NW, and Au NP/CdS NW have been successfully fabricated via the two-stage solvothermal process. Field-emission scan electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) were adopted to characterize the as-prepared products. The optical properties of the as-obtained heterostructures were separately investigated. New insights into understanding and controlling the synthesis of different NW heterostructures are demonstrated in the reliable solvothermal route. We demonstrate that CdS NWs synthesized for 2h are the bifunctional mediator acting as catalyst or active spot for the growth of NW heterostructures Furthermore, understanding and controlling this phenomenon is a great asset for the realization of the formation mechanism of the NW heterostructures and opens up new ways toward for construction of other semiconductor heterostructures with novel properties. Introduction Semiconducting nanowire (NW) heterostructures with modulated compositions and/or doping are at the forefront of the current scientific revolution of nanoscience, which is increasingly important in the assembly of electronic and photonic devices. Compared with notable progress in the NW preparation for the homogeneous systems, the desired one-dimensional (1D) heterostructure formation with well-defined interfaces has been lagging far behind in the past few decades. 1 Furthermore, the control over the selective location of metallic/semiconductor domains on the surface of semiconductor nanocrystals (NCs) and the quality of the interface between them are very important issues when considering the possible use of such types of heterostructures in electronic devices. It is well known that there are two types of solution routes in the literature for creating nano-objects with heterostructures. One is the seeded growth.2-5 Another is the catalyst-assisted growth.6-10 In the seeded growth, the second materials epitaxially grow on the suitable crystallographic facet offered by seeds, which lead to heterostructure nanomaterials. Therefore, a proper lattice mismatch between the growing crystallographic facets of two different types of nanomaterials and accurately controlling the surface states of seed are required in the seeded growth, which are difficult and limit the wide use of the method. In catalyst-assisted growth, a metal or alloy with a low melting point is mainly used as a catalyst for growing NWs. Compared with the catalytic growth of semiconductor NWs, the catalytic growth of 1D semiconductor-semiconductor nanoheterostructure is quite rare. Recently, the catalytic fabrication of Cu2S-In2S3 heterostructure by using Cu1.94S NCs as a catalyst has been reported by the Han et a l.11 Xu et al demonstrate that Ag2S NCs are the catalyst for the preparation of semiconductor-semiconductor heterostructures such as construction of Ag2S-ZnS, Ag2S-CdS, Ag2S-CdS-ZnS.10 They think that Ag2S is a kind of fast ion conductor and Ag cations in Ag2S behave like a “fluid”; therefore, although Ag2S is a stoichiometric compound, there are a lot of cation vacancies in Ag2S NCs.10,13 This unique feature would enable Ag2S NCs potentially to be an excellent 181 All rights reserved. No part of contents of this paper may be reproduced or transmitted in any form or by any means without the written permission of TTP, www.ttp.net. (ID: 210.28.142.44, Nanjing University of Posts and Telecommunications, Nanjing,Jiangsu, China-23/01/14,11:24:12) ! } "" ~! } # ! ! ! )*+" " , # ! 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YOy +JK*J+J)D#J! [E@14&yT.&V] 03.N:’ 8=.’ ?0 Recognition Of MicroRNA-binding Sites In Proteins From Sequences Using Laplacian Support Vector Machines With A Hybrid Feature ǡ ǡ ǡǡ ǡ ǡ ǡʹͳͲͲͶǡǤ Ǥ Abstract—The recognition of microRNA (miRNA)-binding residues in proteins would further enhance our understanding of how miRNAs silence their target genes and some relevant biological processes. Due to the insufficient labeled examples, traditional methods such as SVMs could not work well on such problems. Thus, we propose a semi-supervised learning method, i.e., Laplacian Support Vector Machine (LapSVM) for recognizing miRNA-binding residues in proteins from sequences by making use of both labeled and unlabeled data in this article. A hybrid feature is put forward for coding instances which incorporates evolutionary information of the amino acid sequence and mutual interaction propensities in protein-miRNA complex structures. The results indicate that the LapSVM model receives good performance with a F1 score of 22.06±0.28% and an AUC (area under the ROC curve) value of 0.760±0.043. A web server called MBindR is built and freely available at http:// cbi.njupt.edu.cn/MBindR/MBindR.htm for academic usage. Keywords-Laplacian Support Vector Machine; miRNA-binding residues; evolutionary information; mutual interaction propensities I. INTRODUCTION A microRNA (miRNA) is a small non-coding RNA molecule found in plants and animals, which functions in transcriptional and post-transcriptional regulation of gene expression[1]. A microRNA usually results in gene silencing via translational repression or target degradation by pairing to messenger RNA transcripts (mRNAs) of proteincoding genes [2]. MicroRNAs are playing an important role in a range of diseases such as cancer, inherited diseases, heart disease, the nervous system, obesity[3]. Their involvement in many physiological pathways, makes them an excellent target for pharmaceutical drug development and their use as biomarkers or for profiling and screening turns them into a valuable tool for diagnostics[4]. The process of miRNAs for silencing target mRNAs is performed by RISCs (RNA-induced silencing complexes) in which the main catalytic subunit is one of the Argonaute proteins (AGO), and miRNA serves as a template for recognizing specific mRNA sequences[5]. Consequently, the recognition of miRNA-binding residues in RISCs can significantly improve our understanding of how miRNAs silence target genes and many related biological processes, and also can provide further insights into protein Corresponding author.E-mail address:jansen@njupt.edu.cn (J. Wu). We would like to acknowledge the support by the National Natural Science Foundation of China (No.61203289, No. 61205057, 61305072), Natural Science Foundation of the Higher Education Institutions of Jiangsu Province (No.12KJB520010), the Open Research Fund of State Key Laboratory of BioelectronicsˈSoutheast University (No.BK212001)ˈChina Postdoctoral Science Foundation(No.20110490129, No.2013T60523) and Postdoctoral Science Foundation of Jiangsu Province(No.1102013C). 183 functions and mechanisms of protein - miRNA specific interaction. Recently, various computational methods have been developed to recognize RNA-binding residues in proteins directly from amino acid sequences [6-10]. As we know, there are many types of RNA molecules with diverse structures and the mechanism of different RNA molecules recognizing their protein partners is not exactly the same. Thus, it is not easy to identify the ground-truth miRNA-binding residues in proteins by the RNA-binding residue prediction methods. Is it possible to develop a computational method specifically for recognizing miRNA-binding residues in proteins? Currently, there are few available structures of proteinmiRNA complexes in the Protein Data Bank (PDB) database[11]. Thus, it is difficult to build an ideal computational model for predicting miRNA-binding residues in proteins due to insufficient labeled examples. So far, there is not a computational method specifically for predicting miRNA-binding residues in proteins from sequences. Meanwhile, we observe that numerous miRNA-binding protein sequences can be obtained from the UniProt database (http://www.uniprot.org/)[12]. Such sequences prepare sufficient unlabeled data for constructing classifiers to predict miRNA-binding residues in proteins. Therefore, it is a good choice to use semi-supervised learning methods for building miRNA-binding residues prediction models by making use of both labeled and unlabeled data. In the present study, we will attempt to build anoptimal model for predicting miRNA-binding residues in proteins from sequences. In order to train a perfect prediction model, the following points will be taken into consideration. (1) There are multiple semi-supervised learning algorithms [2, 13-15], and it is important to find a fast and efficient semi-supervised learning algorithm for our task. (2) Nucleic acid molecules can recognize specific structural motifs in proteins. Such motifs are more conserved in evolution, and usually have preferences in physico-chemical properties. Therefore, it is beneficial for predicting miRNA-binding residues in proteins to obtain novel feature descriptors by analyzing preferences of physicochemical properties in miRNA-binding regions and mining correlations among different properties. (3) The number of miRNA-binding residues in proteins is greatly less than that of non-binding ones. In situations where the minority class is more important, the F1 score is a more appropriate measure, Chapter 201 Research on Construction of Bilingual-Teaching Model Course for Bioinformatics Dong Hu, Jiansheng Wu, Han Wei, Meng Cui and Qiuming Zhang Abstract Bioinformatics is an important professional basic course in Biomedical Engineering, which tells about the important theoretical basis of using information technology in modern medicine and biology. In order to build a bilingual model curriculum and bring up the comprehensive talents who can make active learning and have creativity and teamwork spirits, we should actively explore the teaching system that suits the bioinformatics bilingual curriculum and train a high-quality teaching team. In addition, we also need to accumulate teaching resources for students’ independent learning, create an independent learning environment, expand the opportunities for communicating the results of course reform. Model curriculum Keywords Bilingual teaching Bioinformatics CLC number: Q811 Curriculum system 201.1 Preface Twenty-first century is the era of life science, the information age. The bioinformatics has developed rapidly since it was born internationally in 1987. Broadly speaking, bio-informatics is a discipline that uses theories, techniques, methods of mathematical and information science to study the phenomenon of life, organize and analyze the biological data that presents exponential growth [1]. It reveals the biological significance behind the data by acquiring, processing, D. Hu (&) J. Wu H. Wei M. Cui Q. Zhang School of Geographic and Biological Information, Nanjing University of Posts and Telecommunications, Nanjing, 210046 Jiangsu, China e-mail: hud@njupt.edu.cn J. Wu e-mail: jansen@njupt.edu.cn S. Li et al. (eds.), Frontier and Future Development of Information Technology 1737 in Medicine and Education, Lecture Notes in Electrical Engineering 269, DOI: 10.1007/978-94-007-7618-0_201, Springer Science+Business Media Dordrecht 2014 184 2013 6th International Conference on Biomedical Engineering and Informatics (BMEI 2013) Fabrication and Characterization of Silicon Nitride Nanopore Lingzhi Wu1,2, Hang Liu1, Yuqi Liu2, Hao Chen2, Quanjun Liu1*, Zuhong Lu1* 1 2 State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China School of Geography and Biological Information, Nanjing University of Posts and Telecommunications, Nanjing 210046, China paper, we employed focus ion beam to fabricate nanopore with controllable diameters in a silicon nitride membrane, which is supported by a thick silicon substrate. A set of nanopores with different diameters and shapes are fabricated by focused ion beam. Subsequently, the designed nanopore devices are characterized by scanning electron microscope and patchclamp technique. The geometry of nanopore can be controlled by the action time of ion beams at the fixed accelerated potential. The larger nanopore are prepared by longer drilling time. Ionic currents through the open nanopore are steady with low noise by the applied voltages. The well-defined nanopore is employed to monitor the transition of nucleic acids. Upon addition of λ-DNA, typical current drops are observed corresponding to the translocation of single DNA molecule across the pore. Translocation events are characterized by current blockage and translocation time. The statistic histograms of current blockage signals have been studied in our work. Abstract—Nanopores have become an important tool for molecule detection at single molecular level. In our work, the solid nanopore in silicon nitride membranes are fabricated and characterized by experiments. Firstly, the free-standing silicon nitride membranes are designed and etched by delicate techniques. Then, the free-standing membranes are drilled by focus ion beam. A set of nanopores with varied diameters and shapes are fabricated by different acting time of focused ion beam. These nanopores display the high quality of morphologies and electric signals. In addition of DNA, a series of evident block currents appear corresponding to the translocation of single DNA molecule through the pore. The results will shed light on the engineering of nanopore devices for single-molecule sensing. Keywords- nanopore; silicon nitride; focused ion beam; block currents I. INTRODUCTION Over the last decades, nanopores have evolved into powerful and indispensable devices for the investigation of unlabled molecules at the single-molecule level, which is of obvious interest for the low-cost and high-throughput DNA sequencing applications. It was firstly reported in 1996 by Kasianowicz and co-workers on the biological pore αhaemolysin that can distinguish single-stranded DNA and double-strand DNA [1]. However, the fixed small size (diameter ～ 1.3 nm) and instability of the α-haemolysin nanopore limits its application. More recently, artificially fabricated (solid state) nanopores have increasingly gained attention. A variety of techniques have been used to fabricate the pores, including direct drilling with a tightly focused highenergy electron or ion beam [2-4], shrinking of pre-patterned larger openings with a defocused electron or ion beam (‘‘sculpting’’) [5-7], and ion-track etching techniques [8-10]. The solid nanopores are good candidates for such biological molecule sensors with the advantage of long-term stability and controllable pore size and shape. The nanopores have been exploited as inexpensive and ultrafast sensors for the detection and discrimination of different biomolecules, including DNA, RNA and proteins. Figure. 1 The fabrication of the free-standing silicon nitride membrane (a) Wash with piranha solution and ultrasonography, (b) Deposition with 300 nm silicon dioxide (SiO2), (c) Deposition with 100 nm SiN, (d) Deposition with 500 nm SiN, (e) Lithography, (f) Etching with SiN, (g) Etching with Si. As nanopore used for analytical tools grows, it is desirable to have simple fabrication methods available that employ machinery and techniques widely accessible. In this 978-1-4799-2761-6/13/$31.00 ©2013 IEEE 185 363 !""#$% TUVW E,,FGHGIC@J, )CKL@7G ???8@AB86C;8@D !"#$ & % ' ( &" ) * ' +( &=9>&=% )*+), -./0123.*), 3.4.*), 5678&9, 468', ):;8, !9<$( &=9>&=% ,-./0123456789: !"# !"###$%& $"###' ( !"###) * !"###+ ,! !"# !"#$%&'()*+,-&./ !" $!%%&'0 $"# !"#$%&123&)45&./ !" $!%%&' ;<=+> $%!&(%)*$+6 ?@=+> $%!&*%+*$$ ABCD>789:3&;<=>?@,'!!%!%)'-/ !"#$A&B3C; OPQR $ST ,%$)-2)2'''1)/ 6*789:T ;;:9<=>?9@=789:"AB7 IJ> 纳米孔是目前单分子检测的一项重要技术! 除了 C/D " 蛋白质也成为纳米孔研究的重点 对象! 作者以血清蛋白为例" 研究了蛋白质在氮化硅纳米孔中的易位行为" 并对蛋白质的 易 位 事件进行了分析! 和 C/D 相比" 蛋白质本身的荷电和结构特性" 使其进入纳米孔的通量较低" 同时" 蛋白质和纳米孔表面存在吸附现象" 减慢了蛋白质在纳米孔中的易位速度! 当电压 增大 时" 蛋白质的易位事件增加" 过孔速度加快" 吸附现象减弱! 不过" 在高电压 下" 蛋 白 质 在 电 场力的拉扯下构象发生变化" 出现部分或者全部解折叠! 这些结果表明纳米孔提供了一个独特 的获得蛋白质结构和功能信息的检测平台" 可为蛋白质相关疾病的诊断和治疗提供技术支持! KLM> 纳米孔# 蛋白质# 蛋白质吸附# 蛋白质解折叠 5NOPQ> E'& !"#> !%"1+$&F3G"H"!$'%"$%!&"&%%'' R S *+UKVWXYZ[\]^_`aR bcde fghijklm*+Unop_* qrlR stuv*qU_+dwxe yz{|},~op I!J !55' >R K8L98 I$Ja !* ,!*MN-bcd[\`R C/D D O/D gR [\`CHh ¥¦E Y;R Z4 ¡h¢£R 4[\`¤ I1J $%%! >R N9 § ¨©ªyfg«Y¬®¯j°±²³[\´h`µ ¶· [\`h¸¹ºªe ]»A¼½¾e o¿ºÀ§ÁÂ/ AAÃÄ[\` ¡_CHÅÆ Ç C/D/ bcd§*+g¤¥[\`ÈghopCHsÉ ÊĘ̈©$ ÍÎÏ_ÐÈÑ(/ [\`Ybcd}ÒÓ)yÔÕÖ×A_ØÙ Ú bcdg¢Û[\`/ ÜÝ$Þß_à^e áâDãäyåæçbcdYèKhU éDê^R ë}ÓÉe ìÖí$e ÒîïUðñòrº§óºI&P+JR ôstCHbcdhÒ ÓDyõöop_R ÷øR ½ùúEûüýbcdgY*+Un_ijþ kR ¥ÿ!"*+Un_+dþkD,~æçÙ4 #ËR D C/D $%R bcd&'(ó_+(&óºR )*[\`YbcdÈ &=9 186 !""#$% RSTU E++FGHGIC@J+ (CKL@6G ???7@AB75CD7@; !"#$ & % ' ( &" ) * $ +' &88=&8> ()*(+ ,-./012-)(+ 2-3-)(+ 4567&8+ 357$+ 9:;7+ !8<$' &88=&8> ,-./0123456 !"#!"""$ %!"""&'(!""") *!"""$+, !"#$%&'()*+,-&./ !" !"##$% 789+: !#"$&#'&"(0 ;<9+: !#"$&#%&!# =>?@: 12345&6789:;)%""#"#'%*< !"#$%&=5>67:;+,-!"(".'*< ?@A>B CD+"/#(!01"("#*EF1GHI5&67+!#""#$2"((2* ABCD: JKL< $MN +#!'*.'.%%%('O 3&4567P 897:;<=9>?@AB9@C< EF: 作为一种重要的单分子检测技术! 纳米孔的表面特性 至 关 重 要" 作 者 利 用 聚 焦 离 子 束 刻 蚀方法制备得到了一系列形貌可控的氮化硅纳米孔! 并对纳米孔进行了表面改性修饰" 结果发 现! 经过化学处理的氮化硅表面具有大量的硅羟键! 非常利于和硅烷发生反应! 从而在纳 米 孔 表面引入活性基团! 如氨基# 正辛基和巯基等" 通过对修饰有不同硅烷的纳米孔的表面特 性和 电导特性的研究发现! 当硅烷分子将氮化硅表面的硅羟键变为其它功能基团时! 材料表面电荷 会发生变化! 亲# 疏水性也发生变化! 从而导致电渗流的改变! 影响纳米孔 的 电 导" 同 时 ! 修 饰硅烷分子后! 材料表面的电荷特性发生了改变! 也会导致纳米孔器件的膜电容减小! 介 电 噪 声降低" GHI: 纳米孔$ 氮化硅$ 硅烷化修饰$ 电导 JKLMNO D%$ !"#: "#@(/!$E0F@G@"!%#@!#"$@$##'. 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15.学生发表论文及专利.pdf
